Pulmonary arterial hypertension: available treatments in the modern era

Authors

  • Giovanna Manzi Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Gianmarco Scoccia Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Francesca Ileana Adamo Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Annalisa Caputo Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Jean Pierre Jabbour Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Giulia Manguso Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Tommaso Recchioni Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Giovanni Rubino Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Giorgia Serino Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Weili Marco Xu Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Silvia Papa Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Carmine Dario Vizza Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy
  • Roberto Badagliacca Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy

DOI:

https://doi.org/10.56823/YORY4349

Abstract

The several randomized controlled trials (RCTs) conducted in the last 25 years in the field of pulmonary arterial hyper- tension (PAH) have led to the approval of over 10 drugs, which seek to restore the right balance between vasoconstrictor and vasodilator factors, and to the consequent increase of the median survival. However, no medical treatment is currently curative. Ongoing research is focusing on how to preserve right ventricle (RV) function, curbing the inexorable progres- sion of the disease towards right heart failure and death. Below, we provide a comprehensive review of the current available PAH specific therapies and briefly report the therapeutic strategies adopted by PH specialists in clinical practice.

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Published

2022-12-09

Issue

Vol. 1 No. 1 (2022): MAJ 2022

Section

Articles

License

Copyright (c) 2022 Giovanna Manzi, Gianmarco Scoccia, Francesca Ileana Adamo, Annalisa Caputo, Jean Pierre Jabbour, Giulia Manguso, Tommaso Recchioni, Giovanni Rubino, Giorgia Serino, Weili Marco Xu, Silvia Papa, Carmine Dario Vizza, Roberto Badagliacca

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Ma.CRO Lifescience Srl has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

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